The match could start at around 13.30 Latvian time.
Ostapenko is in tenth place in the WTA ranking and is seeded ninth in the tournament, while the Spaniard ranks 93rd in the world ranking. The two tennis players have not met before on the court.
The Latvian tennis player was free from the first round, participating in the tournament only from the second round. On the other hand, Bouzas-Maneiro, after overcoming two qualification rounds, beat Paula Bados (WTA 101.) 2-6, 6-3, 6-3 in the first round of the main tournament.
Ostapenko has won two titles this season and has a 17-7 win-loss record. In March, the 21-year-old Bouzas-Maneiro won her first WTA 125 title, winning the tournament in Antalya on clay.
In the third round, the winner of the match will meet the Russian Veronika Kudermetova (WTA 19th) or the Argentine Maria Lourdes Carla (WTA 82nd).
Ostapenko will also compete in the doubles tournament with her usual opponent Ludmila Kichenoka from Ukraine, in which the Latvian and Ukrainian duo is seeded fifth.
The tournament in Madrid takes place on clay courts.
